Progesterone receptor membrane component 2 regulates the neuronal activity and participates in epileptic seizures in experimental mice

It was found the expression of progesterone receptor membrane component 2 (PGRMC2) in histone epileptic mice lower than that normal mice. In this study, we by immunofluorescence technique, PGRMC2 expressed both astrocytes and neurons mouse hippocampus. addition, seizure latency grade each group were observed after stereotactic injection knockdown virus, overexpression lentivirus, related null virus into hippocampus PTZ + siPGRMC2 prolonged compared with group. The shortened number IV above seizures significantly reduced, while increased. nerve cells still intact. group, neural damaged, intercellular space widened, reduced. These findings support may be involved seizures.